GERD is a disease in which reflux of gastric contents causes uncomfortable symptoms and/or complications. The typical symptoms are reflux and heartburn (burning sensation in the retrosternal region), but some patients never have symptoms or have atypical symptoms such as asthma, hoarseness, sore throat, cough, etc. Patients with GERD may have difficulty inhaling at night when they feel a spasm in their larynx during sleep, and may easily wake up in the middle of the night due to breath-holding, and may even have symptoms such as nausea and heartburn. These symptoms often mislead patients to believe that they have asthma, while ignoring the true cause of the disease. To distinguish between asthma and GERD, one can start by understanding whether the patient’s symptoms are related to allergens. Common asthma often has allergens such as pollen and dust mites, and the condition can worsen or lessen with seasonal or environmental changes, with dyspnea being the main cause. In contrast, gastroesophageal reflux disease is a common digestive system disorder with no obvious allergens and no seasonal distribution. The PPI standard therapy trilogy for GERD is ineffective in treating asthma alone after symptoms have developed. According to studies, asymptomatic GERD is present in most asthmatic patients, but in most cases, one disease exacerbates the subclinical symptoms of the other. In other words, treating asthma alone does not fully work, but rather a two-pronged approach is needed to treat GERD accordingly as soon as possible after it is diagnosed. In October 2007, the Gastrointestinal Dynamics Group of the Chinese Society of Gastroenterology published the first domestic Consensus Opinion on the Treatment of GERD in the Chinese Journal of Gastroenterology. It standardized the dose and course of GERD treatment and proposed proton pump inhibitor (PPI) therapy as the recommended therapy for GERD. There are three main steps in the diagnosis and treatment of GERD: i. Patients suspected of having GERD should be treated empirically with PPI for 1-2 weeks based on typical GERD symptoms such as heartburn and reflux; ii. After GERD is identified, patients should receive a standardized 8-week initial treatment course. The standard dose of PPI is recommended; iii. Remind maintenance therapy to consolidate the efficacy and prevent recurrence according to different patients’ conditions, such as: maintaining the original dose, halving the dose, and on-demand treatment.