The main ways of transmission of AIDS include blood contact, sexual contact, vertical transmission from mother to child, etc., and the main way of HIV infection among adolescents is through sexual contact. Since adolescents have irregular sexual partners and are more open-minded at the same time, young people and adolescents are predominant among AIDS patients. If there is a recent high-risk contact, such as blood or sexual contact, and the late appearance of fever, enlarged lymph nodes, uncontrollable diarrhea, dizziness, headache, sore throat, abnormal rash and a series of clinical symptoms, we should be alert to the possibility of infection. Meanwhile, it is recommended to check the HIV antibody regularly in the later stage, and if the diagnosis is clear, it should be treated in time.