The difference between true cold and false heat and true heat and false cold lies in the nature of the disease as well as its clinical manifestations and etiology. 1. Essence: true cold and false heat means that the disease belongs to the cold evidence, but it shows the appearance of false heat; and true heat and false cold means that the disease is heat evidence, but it shows the appearance of false cold. 2. Clinical manifestations: the manifestations of true cold and false heat are cold limbs (cold limbs, even to the elbows and knees), long and clear urine, pale tongue, but at the same time there is a hot body wanting to cover the blanket, red face, thirst does not want to drink water, sore throat without redness and swelling and other symptoms. The manifestations of True Heat and False Cold are high fever, irritable heat in the chest and abdomen (irritable and sultry), preference for cold drinks, dry throat and bad breath, short and reddish urine (small amount of urine, dark yellow color), and at the same time there is coldness of the limbs (cold limbs, even to the elbows and knees and above), no cold (fear of cold), but malignant heat, and the pulse is slow. 3. Etiology: True Cold and False Heat is due to the weakness of Yang Qi, Yin and Cold, forcing Yang Qi to float outside, Yin and Yang do not meet each other. True heat and false cold is due to the congestion of internal heat, yang qi blocked inside, can not reach the skin caused by the external. Patients who are not feeling well are advised to consult a doctor in time to avoid delays.