Gastroesophageal reflux disease (GERD) is a disease caused by the reflux of stomach and duodenal contents into the esophagus and beyond the esophagus, which can lead to inflammation, erosion, ulceration and even cancer of the esophageal mucosa. Typical symptoms are acid reflux, regurgitation, heartburn, belching, abdominal distension and other digestive symptoms. Extra-esophageal manifestations such as coughing, coughing up sputum, throat tightness, wheezing, aspiration pneumonia, non-cardiogenic chest pain, reflux laryngitis, rhinitis and otitis media can also occur, seriously affecting the quality of life of patients. It is important to point out that many patients with “coronary heart disease” chest pain and “asthma” who have been misdiagnosed as negative coronary angiography for a long time are actually suffering from GERD.