A stenosis of 80% in the middle anterior descending branch usually requires stenting, but it can be left in place temporarily if the result is poor or there are many complications. The indication for coronary stenting is coronary stenosis of more than 75%, and the anterior descending branch is one of the main blood vessels of the heart, and a stenosis of 80% can lead to acute myocardial infarction and other serious consequences, so 80% of the stenosis of the middle anterior descending branch can be put into a stent. If the patient has multiple stenoses in the coronary arteries, which cannot be completely covered by the stent, coronary artery bypass grafting surgery without stenting can be performed as prescribed by the doctor. If the patient has renal insufficiency, active bleeding and other serious diseases, and can not tolerate surgery or postoperative antiplatelet therapy, the stent can not be put in, and the patient should follow the doctor’s instructions to actively treat the primary disease, and at the same time, use drugs such as hemosiderophon, atorvastatin, etc. to expand the blood vessels, lower the lipid, and alleviate the symptoms. In case of 80% stenosis of the middle anterior descending branch, the patient should consult the doctor in time and choose the appropriate treatment method after examination and evaluation by the doctor, so as to avoid serious consequences. Internal Medicine: Interpretation of the Latest Guidelines for Percutaneous Coronary Interventions