Recently, the “pertussis vaccine” has caused a lot of controversy, vaccination is still the most economical, most direct and most effective means of preventing pertussis, diphtheria and tetanus, but at the same time, at the same time, we need to have knowledge of these diseases. 1, whooping cough Whooping cough is an acute respiratory infectious disease caused by Bordetella pertussis, the source of infection for whooping cough patients, through droplet transmission. Clinical symptoms are paroxysmal spasmodic cough, cough inhalation has a special “chicken” like high-pitched sound, cough symptoms can last 2-3 months. This disease occurs in children <5 years old, especially <6 months of infants with a higher incidence. In the 1960s and 1970s, the annual incidence of pertussis was 100/100,000-200/100,000 in China. Since the 1960s, vaccination against pertussis has been started, and pertussis vaccine has been included in the national immunization program since 1978, and the incidence rate has decreased substantially after the universal use of pertussis vaccine.Since 2008, the reported incidence rate of whooping cough nationwide has been controlled at less than 0.5/100,000.In 2016, there were 5584 cases of whooping cough in China, with an incidence rate of 0.4074/100,000; there were 0 cases of diphtheria; and there were 117 cases of neonatal tetanus 117 cases, incidence rate 0.0114/100,000. 2017 whooping cough incidence 10,390 cases, incidence rate 0.0114/100,000. Although the incidence rate of whooping cough in China has been maintained at a fairly low level (<1/100,000) after pertussis vaccination. However, according to WHO statistics, the resurgence of pertussis has occurred in several countries around the world in recent years, such as the United States, Canada, the United Kingdom, Australia, South Korea and Japan. According to the epidemiological profile of statutory infectious diseases released by China CDC, the incidence of the disease has been increasing significantly in recent years. Diphtheria Diphtheria is an acute respiratory infectious disease caused by Corynebacterium diphtheriae. It is a disease that spreads easily and occurs rapidly. Its clinical features are the formation of grayish-white pseudomembrane of the mucous membrane in the pharynx and larynx, and the systemic toxemia symptoms such as low fever, malaise, nausea and vomiting caused by diphtheria exotoxin, and the severe cases can be complicated by myocarditis and peripheral nerve paralysis. Diphtheria has been a disease that has almost been eliminated in our country, and the statistical report from 2007 to the end of 2017 shows that there is no diphtheria case report in the country. 3, tetanus Tetanus is a specific infection in which Clostridium tetani invades the human body through skin or mucous membrane wounds, grows and multiplies in an anoxic environment, and produces toxins that cause myocardial spasm. Tetanus bacillus is a specialized anaerobic bacterium, widely distributed in nature, can exist in dust, soil, human or animal feces, etc., mainly through the skin or mucous membrane wound invasion of the human body, commonly found in patients with trauma and burns, unclean delivery of newborns and surgical equipment disinfection laxity. In 2017, there were 93 cases of neonatal tetanus , with an incidence rate of 0.0059/100,000 . Neonatal tetanus 93 cases , incidence rate 0.0059/100,000 . Tetanus is not a legally reported infectious disease in our country except for neonatal tetanus.