As the human rabies vaccine is inactivated, only the protein shell of the virus, without its genetic material, the virus will not replicate itself after entering the body. The adverse reaction to vaccination is the reaction of heterogeneous proteins entering the bloodstream, which is equivalent to a bunch of cold viruses entering the human body, but these cold viruses do not replicate themselves, for example, if they enter N, then it is these N, and they will not become more. Typically, the adverse reaction is a low-grade fever, which occurs because the body thinks the virus has entered and activates its own immune response against the invading virus, hence the fever. Since the virus in the rabies vaccine does not replicate itself, it is quickly phagocytosed by the body’s macrophages and expelled from the body, and prompts the body to produce antibodies so that when the same protein shell, the actual rabies virus, appears the next time, it can be quickly neutralized. Also because the virus in the vaccine does not replicate itself, there is only a low fever, not a high fever. A small number of people can experience a vaccination reaction to rabies vaccination, which may be accompanied by headache, dizziness, nausea, malaise, and peripheral malaise, and usually lasts for 1-2 days. Individual vaccinees may experience gastrointestinal symptoms such as nausea, vomiting, and diarrhea, which are usually seen on the day of vaccination and rarely last for 2-3 days. These reactions are caused by the inherent characteristics of the vaccine itself, the body will only cause a transient physiological dysfunction of the reaction, the occurrence of mild systemic reactions to strengthen the observation, generally do not need any treatment, and will not produce lifelong effects. If necessary, take proper rest, drink plenty of boiled water, pay attention to keep warm, and prevent secondary diseases. For severe systemic reactions, such as high fever that does not go away or other complications, the condition should be closely monitored and hospitalization is necessary. Individual dogs or other animals injected with rabies vaccine may have localized spasms or some parts of the nervous system are damaged, this is because the resistance of animals is stronger than that of humans, so in order to activate the immune response of animals, the veterinary rabies vaccine is made into an attenuated vaccine, which has a certain degree of toxicity, so when the animals are vaccinated, if they have a poor resistance, they may be harmed by the vaccine. This is not the case for human beings, unless a fake vaccine is used or a canine vaccine is used as a human vaccine, which is dangerous because those vaccines are attenuated and highly toxic and may damage the human nervous system. There is no danger in injecting human vaccines at a regular vaccination facility.