Rabies vaccine is a person is bitten or scratched by animals need to be vaccinated after the prevention of rabies, to help people eliminate animal bites or scratches into the human body after the rabies virus, people infected with rabies virus once the disease develops, the case fatality rate of one hundred percent. So by dogs, cats, foxes, raccoons and other warm-blooded mammals, including rabies, which also includes the disease of rabies bite or scratch, can be sufficiently washed with soapy water, and then rinse the wound with water, rinse the wound for at least 15 minutes, and then immediately go to the nearest health care institution with a rabies clinic rabies vaccine, the optimal time for injection within 24 hours. The best time for injection is within 24 hours. When injecting rabies vaccine, the whole process must be injected, and there are two types of vaccination programs: the 5-needle method and the “2-1-1” method. For general bite wounds, one dose of rabies vaccine should be given at 0 (the day of injection), 3 (the fourth day, and so on), 7, 14, and 28 days, and the same dosage should be given to children. For severe bites (grade 3 exposure), in addition to the injections described above, passive immunization preparations are required, either anti-rabies serum (40 IU/kg body weight) or rabies immune globulin (20 IU/kg body weight). Some rabies vaccines have been approved for use in China using the “2-1-1” method: 2 doses of vaccine on day 0 (1 dose each in the deltoid muscles of the right and left upper arms), 1 dose on day 7 and 1 dose on day 21, for a total of 4 doses (only for rabies vaccines approved for use in China using the “2-1-1” procedure). (only for rabies vaccine products that have been approved to use the “2-1-1” procedure in China), this procedure is 1 dose less than the 5-shot method, but it can reduce the number of trips to the hospital, which saves social costs. Pre-exposure prophylaxis for high-risk groups, vaccination shot in advance, can be 0, 7, 21 (or 28) days injection of 3 injections, and later monitor the level of antibodies, when the level of antibodies is less than 0.5IU / ml to strengthen the injection of 1 dose. Where the vaccine 1 day before the injection of anti-rabies serum, chronic patients such as cirrhosis, immunodeficiency, taking immunosuppressive drugs, the elderly, severe malnutrition and bite wounds 48 hours before the start of immunization and other 7 cases, should be in the initial vaccination plus 2-3 times the amount of vaccine, sub-parts of the injection, in order to have a better immune effect. In addition, some minor injuries, but the amount of invasive virus is large or the injury is rich in nerve areas (such as the head, face, hands, perineum), there can also be a short incubation period and the vaccine alone is ineffective, these parts of the second level of exposure also need to be in accordance with the third level of exposure, and at the same time the use of rabies immune globulin or antirabies serum.