There are many possible reasons for the persistent lowering of blood pressure in uremia, such as dialysis reasons, inappropriate use of antihypertensive drugs, poor cardiac function and so on. Uremic patients with low blood pressure during dialysis may be due to low sodium concentration of dialysis fluid, dialysis speed is too fast, etc. Generally, blood pressure can gradually return to normal after stopping dialysis. If the blood pressure is too low in daily life, it may be the problem of antihypertensive drug dosage, and the drug dosage should be adjusted in time to avoid blood volume insufficiency. Most uremic patients will have cardiac insufficiency, when the pumping function of the heart decreases, and the reduction of per-pulse output (the amount of blood output per contraction of one side of the ventricle) will lead to a certain decline in blood volume, and therefore the blood pressure will be lowered. In summary, uremic patients with persistent lowering of blood pressure should be promptly to the hospital to find out the cause, and follow the doctor’s instructions to adjust the treatment program in a timely manner.