There are many reasons why male non-gonococcal urethritis is difficult to treat, such as not standardizing the use of medication, treatment is not complete, sex life each other with hidden infections, the body has chronic diseases and other reasons. 1. not standardized medication: male non-gonococcal urethritis, if not in accordance with the course of non-standardized medication is likely to cause the disease, recurrence, resulting in male non-gonococcal urethritis difficult to cure. 2. treatment is not complete: through the treatment of symptoms relief, they casually stop taking medication, did not follow the doctor’s orders according to the course of medication, will lead to treatment is not complete, just symptoms relief or disappearance, will also appear male non-gonococcal urethritis difficult to cure. 3. Sexual life each other have hidden infection: men through the treatment of the body recovery, if sexual life each other body have pathogenic bacteria, women did not have disease, but may be through sexual life to the pathogenic bacteria infected to men, thus leading to male non-gonococcal urethritis difficult to cure. 4. The body has a chronic disease: its own physical weakness or anemia, malnutrition, chronic tumors, diabetes, AIDS and other diseases, will also lead to male non-gonococcal urethritis difficult to cure. Male non-gonococcal urethritis is difficult to cure, there may be other reasons, need to go to the regular hospital in time to check, follow the doctor’s instructions for treatment.