Patients with advanced pancreatic cancer doing nerve block may have the risks of drug allergy, damage to nerves, local infection and so on. 1. Drug allergy: people who are allergic to anesthetics can have allergic reactions such as skin itching, rash, respiratory difficulty, arrhythmia and so on, and people with allergic body should be cautious of using this kind of drugs. 2. Damage to nerves: nerve block in advanced pancreatic cancer patients can play the role of pain relief, which can alleviate the pain of patients, but nerve block is a kind of minimally invasive surgery that can damage the nerve function, which can cause numbness and other sensory abnormalities. 3. Risk of infection: If the site of nerve block is not sterilized well, it can be contaminated by pathogens, which may cause local infection. Patients with advanced pancreatic cancer should do nerve block under the guidance of physicians, do not self-medication to avoid adverse results.