The late stage of esophageal cancer refers to the advanced stage of esophageal cancer, in which the scope of lesions is wide and distant metastasis can occur, so endoprosthesis therapy, drug therapy, radiation therapy and other therapies need to be given to address the condition of the patients in the clinic. 1. Endoprosthesis treatment: Since patients with advanced stage of esophageal cancer mostly have distant metastasis, so they cannot be operated. For patients with esophageal obstruction and inability to eat, endoprosthesis implantation can be given to solve the problem of esophageal obstruction and inability to eat. 2. Chemotherapy: For patients who cannot be treated by surgery or after surgery, chemotherapy can be given to patients, and the more common chemotherapy drugs in the clinic are 5-fluorouracil, cisplatin, paclitaxel, etc., and the specific chemotherapy program varies from person to person. 3. Radiation therapy: For patients with advanced esophageal cancer, surgery alone cannot cure it, so radiation therapy can be given to them in combination with their conditions, especially squamous cell carcinoma patients are more sensitive to radiation therapy, which has better therapeutic effect. 4. Other therapies: besides the above therapies, targeted therapy, such as trastuzumab, gefitinib and other drugs, as well as symptomatic and supportive therapies, such as codeine and other drugs for pain relief, can also be given. It is recommended that patients go to the hospital, complete the auxiliary examination, clarify the patient’s condition, and give the relevant treatment for the condition, and the drugs need to be used under the guidance of a professional physician.