Calf edema with pain on pressure may be caused by muscular factors, phlebitis or varicose veins, blood clots and other factors. 1. Muscle factor: If there is excessive pulling of the calf muscle, it may cause small tears of the muscle fiber, thus causing pain. If there is inflammation of muscle ligaments or fascia, it will cause edema and pain on pressure, which is related to excessive exercise. You can rest appropriately. Appropriate heat or physical therapy can also be used to relieve calf muscle spasms and reduce inflammation. 2. Phlebitis or varicose veins: Phlebitis and varicose veins may cause edema in the calves. Phlebitis and varicose veins can cause swelling or pain in the legs due to poor blood flow back to the legs, and the symptoms are more pronounced when the foot is drooping. You can follow the doctor’s instructions to do more ankle pump exercises to promote blood circulation in the lower limbs. 3. Lower extremity venous thrombosis: If there is lower extremity thrombosis, the early symptoms will appear slight edema and pain, especially after standing for a long time the pain will be more intense, it is recommended that vascular ultrasound as well as angiography for diagnosis. It should be noted that, under the guidance of the doctor, according to the edema of the lower leg, the nature of the pain, duration, relevant examination and other factors for comprehensive judgment, by the doctor to take appropriate therapeutic measures, the patient needs to comply with medical advice.