Down screening 1:380 is generally not serious and is a critical risk. When screening a fetus for Down’s syndrome, it is generally considered that test results between 1:270 and 1:1,000 are considered to be at critical risk, and a Down’s syndrome test result of 1:380 is within the range of critical risk, and the presence of such a result indicates that there is a certain chance that the fetus has Down’s syndrome, but the chances are not high. If the fetus has a critical risk, further testing should be done, usually through amniocentesis, non-invasive DNA testing and other methods to determine whether the fetus has Down syndrome. If the results of the tests are all normal, the pregnancy can be safely continued. If the test results are problematic, it often indicates that the fetus has Down syndrome, and effective treatment measures should be taken in a timely manner, in accordance with medical advice.