Dry and rough skin on the hands may be related to lack of moisture, thickening of the stratum corneum, ringworm and other factors, which can be treated by supplementing moisture, exfoliation, drug intervention and other ways. 1. Lack of moisture: the reason for the dry and rough skin on the hands may be related to the lack of long-term lack of care and lack of moisture, you can add more water, eat more vegetables and fruits, and use moisturizing hand cream to apply, you can improve the dry and rough skin. 2. Thickening of the stratum corneum: for long-term heavy manual labor crowd, may be due to excessive use of hands and local stratum corneum thickening, there will be obvious dry and rough phenomenon, you can use exfoliation of skin care products, the hands of the thickening of the keratin removal, and the use of petroleum jelly moisturizing cream compress treatment, improve the skin rough and dry phenomenon. 3. ringworm factor: this is due to dermatophyte infection caused by skin diseases, mainly related to fungal infections, you can cooperate with the doctor external ketoconazole, miconazole, clotrimazole and other medications, if necessary, plus oral terbinafine, itraconazole and other antifungals, to improve the therapeutic effect of the need to strictly comply with the instructions of the doctor to use the drug. It is recommended that patients with dry and rough skin on their hands should cooperate with the doctor to clarify the cause, and then do targeted treatment and treatment, do not self-medication.