Colds with fever after drinking can be treated with antipyretic medications such as acetaminophen, and penicillin or cephalosporin antibiotics are prohibited. If there is a cold and fever, but the presence of alcohol consumption, then the main focus is generally symptomatic antipyretic treatment. Fever-reducing medications such as acetaminophen, ibuprofen, and Xiao Chai Hu injection can be used and are usually symptomatic in controlling fever. Combined with drinking plenty of fluids and rest, most cases can be recovered. However, special attention should be paid not to use antibiotics such as penicillin and cephalosporins, which may react adversely with alcohol and cause symptoms such as panic, sweating and even shock. Therefore, if the effect of fever-reducing treatment is not good, it is recommended to consult a doctor in a timely manner, under the guidance of the doctor to carry out lung CT, blood routine and other tests, and at the same time, according to the doctor’s instructions for treatment.