Ibuprofen and methylcobalamin are, as a general rule, okay to take together, but the medications should be used under a doctor’s supervision. Combining ibuprofen with zidovudine, warfarin, aspirin, clopidogrel, fluvoxamine, paroxetine, lithium carbonate, hydrochlorothiazide, tachyphylaxis, enalapril, propranolol and other medications will lead to drug-drug interactions and should not be used together. Therefore, there is no drug interaction between ibuprofen and methylcobalamin, which can be taken together in general. Ibuprofen is mainly used for pain, fever caused by cold. Adverse reactions can be seen as loss of appetite, stomach upset, abdominal pain, nausea, vomiting, rash, itching, facial edema and so on. The drug is contraindicated for those who are allergic to the product, those with peptic ulcers, pregnant and lactating women. Methylcobalamin is mainly used for the treatment of peripheral neuropathy. Adverse reactions can be seen allergy, loss of appetite, vomiting, diarrhea, nausea and so on. It is contraindicated in people who are allergic to the product. If you need to use ibuprofen and methylcobalamin at the same time, you should consult your doctor and use the medicine reasonably under the doctor’s guidance.