Elevated large platelet ratio should be treated according to different etiologies. Common etiologies include idiopathic thrombocytopenic purpura, acute granulocytic leukemia, etc. Depending on the etiology, glucocorticoid therapy or acute lymphoblastic leukemia chemotherapy regimen can be used. 1. idiopathic thrombocytopenic purpura: excessive destruction of platelets in the peripheral blood of the disease, while the bone marrow is functioning well, will allow the release of larger platelets in advance, resulting in an elevated ratio of large platelets, and various conditions will lead to thrombosis, should be timely treatment of the primary disease, the use of glucocorticosteroids and intravenous gammaglobulin treatment. 2. Acute granulocytic leukemia: acute granulocytic leukemia will lead to a decrease in blood platelets, the underdeveloped platelets in the bone marrow will be released into the blood, which will lead to an increase in the ratio of large platelets and the emergence of acute granulocytic leukemia, which is usually treated with chemotherapy using hypertriglyceride, Zoerythromycin, and desmethyl Zoerythromycin. All of the above medications should be used under the guidance of a physician, and self-medication is strictly prohibited.