Holding the breath in the middle of the night may have sleep apnea syndrome, heart failure, angina and other diseases. 1. Sleep apnea syndrome: patients will appear at night for a long time between breaths, during the respiratory intervals will appear serious hypoxemia, can lead to respiratory difficulties, can be suffocated by the sleep of the patients woke up. 2. Heart failure: patients are prone to waking up at night, the patient’s sleep will cause increased blood volume, increased vagal tone, leading to pulmonary stasis symptoms worsening, hypoxia symptoms can occur at night, waking up at night suffocation. 3. angina: night holding awake also consider the occurrence of coronary angina, some patients can occur at night coronary artery spasm, resulting in acute myocardial ischemia attack, manifested in the symptoms of holding awake. Wake up at night should pay attention to the hospital timely consultation, clear specific reasons, under the guidance of the doctor’s treatment.