Preconception health care mainly includes: 1. Prepare and plan pregnancy, avoiding pregnancy at advanced age; 2. Reasonable nutrition and control of body mass (weight) gain; 3. Supplementation with folic acid 0,4 to 0,8 mg/d or evidence-based medically proven multivitamin containing folic acid. Pregnant women with previous neural tube defects (NTD) should take 4mg of folic acid daily; 4. Women with genetic diseases, chronic diseases and infectious diseases who are preparing for pregnancy should be evaluated and guided; 5. Use medication reasonably and avoid drugs that may affect normal fetal development; 6. Avoid exposure to toxic and harmful substances in the living and occupational environment (such as radiation, high temperature, lead, mercury, benzene, arsenic, pesticides, etc.) Avoid close contact with pets; 7. Change bad habits (such as smoking, alcoholism, drug abuse, etc.) and lifestyle; avoid high-intensity work, high-noise environment and domestic violence; 8. Maintain mental health, relieve mental stress and prevent the occurrence of psychological problems during pregnancy and after delivery; 9. Choose exercise reasonably.