The gold standard for determining whether the anterior mediastinal nodule is malignant is pathological biopsy, which can also be combined with the histomorphology and biological behavior of the nodule to make a preliminary judgment. 1. Pathological biopsy: It can visually observe the nature of the nodule, distinguish whether it is inflammation or tumor, and judge the benign or malignant nature of the tumor according to the degree of cell differentiation, heterogeneity, etc. Benign tumors are often well differentiated, with little heterogeneity. Benign tumors are often well differentiated, with small heterogeneity and no or few pathological nuclear schizophrenia; malignant tumors are often differentiated to different degrees, with large heterogeneity and common pathological nuclear schizophrenia. 2. Histomorphology: benign lesions mostly have complete envelope wrapping, clear boundaries, and rarely see hemorrhage, necrosis, ulcer, etc. Malignant lesions are often surrounded by the periphery of the tumor. Malignant lesions often invade and infiltrate all around, and hemorrhage, necrosis and ulceration are common. 3. Biological behavior: for example, inflammation often has a large number of inflammatory cells infiltration; benign tumors are often expansive or exophytic growth, without metastasis, less compression or obstruction symptoms on the body; malignant tumors are often infiltrative or exophytic growth, metastasis can occur, and have a greater impact on the body. If you find anterior mediastinal nodule, you should go to the regular hospital for relevant examination to make a clear diagnosis.