Low platelet count alone is a condition in which only the platelet count is reduced in routine blood tests in the peripheral blood, the number and ratio of white blood cells are normal, and the number of red blood cells is not reduced or increased. Low platelet count alone can have a variety of causes, such as when a person has a cold. Taking certain medications, such as aspirin or applying heparin, can also result in a lower platelet count. There is a disease in hematology that causes a simple decrease in platelets. This disease is called immune thrombocytopenic purpura, which causes excessive destruction of platelets in the spleen due to the production of autoantibodies against platelets, and is also accompanied by impaired maturation of megakaryocytes in the bone marrow, which eventually causes a simple decrease in platelet count, which is often severe and accompanied by significant bleeding.