Metformin extended-release tablets are long-acting preparations and are recommended for patients with gastrointestinal disorders to be taken with meals or within half an hour to one hour after dinner. Metformin extended-release tablets have certain side effects and can cause significant gastrointestinal reactions, including nausea, vomiting, abdominal pain, diarrhea, etc. Therefore, if there are no obvious gastrointestinal reactions while taking metformin, it can be taken orally before meals. However, those who suffer from gastrointestinal diseases should take it after meals, if they take it once a day, it is recommended to take it after dinner, if they take it twice a day, it is recommended to take it after breakfast and dinner to avoid the gastrointestinal tract irritation of metformin, the specific dose should be taken according to the patient’s condition and under the guidance of professional doctors. In addition to active oral diabetes medication, diabetic patients should also strictly control the intake of sweets, control weight, pay attention to weight loss, control blood glucose in the normal range, and review regularly.