When taking metformin extended-release tablets, the patient’s liver function and kidney function need to be tested before the medication is administered. Usually more attention is paid to kidney function, and if there is kidney insufficiency, metformin extended-release tablets should not be taken. If the patient’s liver and kidney function are normal, Metformin extended-release tablets can be applied. Usually follow the doctor’s advice, start with a small dose, and gradually increase the dose according to the blood sugar and the patient’s gastrointestinal response, which can be taken during or after meals, especially for some patients with gastrointestinal discomfort, taking it after meals can reduce the gastrointestinal response. If a missed dose is found during a meal, it can be taken orally as soon as possible after the meal. If a missed dose of metformin extended-release tablets is found more than 2h after a meal, it is recommended not to take an additional supplement. Also if there is a change in the properties of the tablets, for example, if the quality of the drug is affected due to improper storage in general, it is recommended that the tablets should be replaced with metformin extended-release tablets in new packaging. When taking metformin extended-release tablets for the first time, you can test the blood sugar and observe whether the patient has any discomfort symptoms, if the blood sugar does not appear low and there are no discomfort symptoms such as diarrhea, nausea and vomiting, you can continue to take them. However, if there are these uncomfortable symptoms, or even the performance of abnormal stool, fatigue and dizziness, the drug should be changed under the guidance of the doctor, or the drug dose should be adjusted.