1.Folic acid supplementation from 3 months before pregnancy: 0.4 mg of folic acid daily can reduce the chance of fetal neural tube defects (including anencephaly, brain expansion and spina bifida) by 40%-80%. 2. Medical examination of the mother-to-be: Combined medical diseases such as hypertension, diabetes or abnormal thyroid function can lead to abnormal fetal development, especially mothers-to-be with family history should undergo relevant examination before pregnancy. He Fang, Department of Obstetrics, The Third Hospital of Guangzhou Medical University 3. Avoid toxins in the environment: quit smoking, alcohol, drugs such as heroin, etc. Stay away from places with serious air pollution, electronic product recycling stations, etc. Patients who have had multiple miscarriages can consider moving. 4.Adjust work and rest: pay attention to nutrition, rest and diet