A woman’s natural fertility begins to decline after the age of 35, and although many women are still fertile after the age of 40, typically, most women lose their fertility completely years before menopause. Although assisted reproductive technology (ART) can solve the fertility-related problems of many infertile couples, it does not remedy the situation for all families. The advanced age of women undergoing IVF and the decrease in ovarian reserve function are the main reasons for IVF failure. All women should be aware of the objective fact that advanced age causes a decrease in fertility, and obstetricians and gynecologists have an obligation to educate every woman who intends to have a baby after the age of 35 about the relevant science and inform them about the characteristics of their body’s biological clock. 1. Women over 35 years of age need to know the fact that their chances of conception are significantly lower than those of the younger age group. Women over 40 years of age have only a 1 in 100 chance of conception per menstrual cycle, and if they have not conceived after 6 months of active attempts, a more active approach is to consult a reproductive medicine specialist and receive the necessary medical assistance. 2. For women over 40 years of age, the doctor is obliged to inform the older mother about the risks of pregnancy, including the relatively high risk of miscarriage, the increased risk of pregnancy complications, such as surgical delivery, diabetes, intrauterine growth restriction and low birth weight babies, and the need for screening for certain diseases, such as diabetes and hypertension, before conception. 3. If conditions permit, both partners should undergo a comprehensive medical examination that includes a preconception checkup. Obstetrics and gynecology should include: gynecological examination, cervical cytology screening (currently mainly TCT), ultrasound of the uterus and both adnexa. If financial conditions allow, screening for both high-risk HPV virus and TORCH testing is recommended. 4. Take one 0.4mg of folic acid daily starting three months before the planned pregnancy until three months after successful conception. If the pregnancy is unplanned and there is no folic acid supplementation in advance, as long as women are not extremely paranoid or severely malnourished, they should not overly panic and just start taking it in time. 5. For women with regular menstruation, maintaining a regular sex life (2-3 times/week) since the last clean period can help increase the chance of conception. The 6 days before ovulation is medically defined as the “conception window”, and if you can maintain a frequent sex life within these 6 days (1 time/1-2 days), you will have the best chance of conception. 6.If sex is not so frequent, or if the couple lives in two places or one of them travels a lot, it is recommended to master some methods to predict ovulation, such as measuring basal body temperature and using ovulation test strips, which will be helpful to improve the conception rate. 7. Once you have successfully conceived, you should have prenatal checkups as early as possible. Pregnancies in women over 35 years old are medically known as high-risk pregnancies, with an increased risk of delivering a fetus with chromosomal abnormality/abnormality, and prenatal checkups should be started before the third trimester to give your doctor sufficient time to discuss and provide you with prenatal diagnosis (e.g. NT measurement, or chorionic villus biopsy, Down’s syndrome screening and amniocentesis if necessary, for early detection of (chromosomal abnormalities in the fetus). 8. Healthy diet, exercise and regular routine need not be emphasized, whether or not a woman has given birth, but will benefit for the rest of her life if she keeps doing so. For example, avoid smoking, excessive alcohol consumption, excessive coffee, drug use, exposure to toxins or harmful chemicals. 9, about the mode of delivery: advanced age is not an absolute indication for cesarean delivery, it is recommended to adopt a good lifestyle of healthy diet and regular exercise before pregnancy, and insist on exercise during pregnancy to control weight and avoid oversized fetus, if there is no contraindication for vaginal delivery, advanced maternal age can also be delivered smoothly. 10. Finally, it should be noted that advanced age fathers appear to be at increased risk for spontaneous abortion, certain autosomal dominant genetic disorders, autism spectrum disorders, and schizophrenia. Men should be counseled for these possible risks if they are older than 40 years, although this risk is small.