Some antibiotics may affect the results of syphilis antibody test, such as penicillin, cephalosporin antibiotics may lead to a decrease in RPR titer suggesting false negative. When the human body is infected with syphilis spirochete 4~10 weeks, the serum can produce a certain number of anti-syphilis antigen non-specific antibodies and anti-syphilis spirochete antigen specific antibodies. Hospitals generally check for the syphilis non-specific antibody RPR and syphilis-specific antibody TPPA. Penicillin and cephalosporin antibiotics may lead to a decrease in RPR titer suggesting false negatives. Therefore, before the syphilis examination, try not to carry out drug treatment, so as not to interfere with the results of the examination, resulting in misdiagnosis and omission of diagnosis, when the patient has a high-risk behavior or uncomfortable symptoms, it is recommended to go to the regular hospital in a timely manner, under the guidance of the doctor to carry out the examination and treatment.