Crohn’s disease (CD) is an inflammatory bowel disease (IBD), a chronic granulomatous inflammatory disease involving all parts of the gastrointestinal tract, the pathogenesis of which has not been elucidated, but is currently thought to be due to autoimmune disorders induced by environmental factors in genetically susceptible people. the peak incidence of CD is concentrated in people aged 15-35 years, with a prolonged and recurrent course, many complications, a high disability rate and a poor prognosis. Our study showed that the rate of bowel resection surgery in our patients is similar to that in Europe and the United States, with rates as high as 16%, 35% and 53% at 1, 3 and 5 years, respectively. However, surgery does not cure the disease, and most patients still have recurrent attacks after surgery, even requiring multiple surgeries, resulting in the destruction of intestinal structure and function, which brings great pain and heavy economic and mental burden to both patients and their families. These traditional treatments are often associated with long-term side effects and have limited efficacy in maintaining clinical remission. In recent years, several large clinical follow-up studies have shown that these medications do not alter the natural course of CD. The number of patients with IBD in China has been increasing over the past 15 years, and the search for new treatments has become a challenge for gastroenterologists in China. Dietary factors play an important role in the development of Crohn’s disease as environmental factors that cannot be ignored. Studies have shown that a high sugar, high fat, low fiber diet and increased use of food additives are closely related to the development of Crohn’s disease. The prevalence of malnutrition in patients with Crohn’s disease is 50-80%, and about 1/3 of adolescent patients have growth retardation. Malnutrition not only causes a decrease in the quality of life of patients, but also seriously affects the efficacy of drugs and increases the incidence of incisional hernia and intestinal fistula in surgical patients. Enteral nutrition (EN) is not only an important means of support in the treatment of Crohn’s disease, but has also attracted widespread attention for its therapeutic effects. EN can induce remission in active Crohn’s disease and has the effect of maintaining remission while improving the nutritional status of patients. In children, EN induces remission equal to or better than glucocorticoids and has been used as the treatment of choice in Europe. In adult studies, the efficacy and cost of exclusive enteral nutrition (EEN) compared with infliximab (IFX) in inducing remission in moderate-to-severe Crohn’s disease was found to be better than IFX in inducing remission while improving nutritional status. In general, EN is effective in relieving patients’ symptoms, promoting mucosal healing, reducing surgical complications, and significantly improving patients’ nutritional status, increasing weight and restoring height growth in pediatric and adolescent patients. promote growth and development, etc. The mechanism of action of EN in the treatment of Crohn’s disease is still under investigation and may be related to the removal of suspected food pathogens that induce the disease, such as allergenic proteins, refined sugars, certain fats, pathogenic microorganisms and parasites; reduction of immune response; adjustment of intestinal flora; direct nutritional effect of EN on the intestinal mucosa, providing raw materials for intestinal mucosa repair (glutamine, pantothenic acid, zinc, fructose, etc.); and intestinal rest. The advantages of nutritional therapy are: ① almost no side effects ② improve the nutritional status ③ induce disease remission, in children the treatment effect is similar to hormone, can induce remission of CD where some other treatments are ineffective ④ can be applied to patients with intestinal fistula, abdominal abscess, promote the healing of intestinal fistula, enterocutaneous fistula, with antibiotics can even make some patients avoid surgery. Nutritional therapy is a new weapon in our hands, and its flexible use can be a boon for many patients with Crohn’s disease!