Crohn’s disease (CD) is a subacute and chronic inflammatory disease of the intestinal tract of which the etiology is not yet clear. It can involve all segments of the digestive tract from the oral cavity to the anus, with the terminal ileum and adjacent colon being the most common. A. What are the common clinical manifestations of Crohn’s disease? 1, abdominal pain: patients often complain of periodic episodes of abdominal pain, mainly postprandial abdominal pain around the umbilicus, occasionally may appear low fever and mild diarrhea. Abdominal pain episodes can be spontaneously relieved and recurred, with increasing frequency and severity, and finally the abdominal pain is concentrated in the right lower abdomen. Sometimes, patients may be seen for pressure pain in the right lower abdomen or even for the discovery of a right lower abdominal mass. Therefore, it is often misdiagnosed as acute appendicitis and abdominal surgery is performed before the diagnosis of Crohn’s disease is clarified. 2, intestinal obstruction: abdominal pain is often accompanied by the characteristics of partial intestinal obstruction, and the symptoms can be aggravated after eating; while rest, warm abdominal compresses and fasting can improve abdominal pain. 3, diarrhea: diarrhea generally rarely exceeds 4 to 5 times a day. Weight loss is more common, and children may have delayed growth and sexual development as the early clinical manifestations of the disease. 4. Peri-rectal or perianal abscess or fistula formation: pain, masses, purulent drainage, etc., with fever. Second, how to regular treatment of Crohn’s disease? 1, amino salicylic acid preparations: effective in controlling the activity of mild and medium-sized patients, and can be used as maintenance therapy in remission. 2, hormone: currently is the control of disease activity effective drugs. 3.Immunosuppressants: Suitable for chronic active cases with poor effect on hormone therapy or hormone dependence, the effect time is about 3-6 months, and the maintenance medication is generally 1~2 years. 4, antibacterial drugs: certain antibacterial drugs such as metronidazole, quinolones have certain efficacy. 5, anti-TNF-α monoclonal antibody: clinical trials have proved to be effective in active Crohn’s disease where traditional treatment is ineffective, and repeated treatment can achieve long-term remission, and is now being used clinically, its efficacy and safety remain to be observed. 6, for patients with complete intestinal obstruction, fistula and abscess formation, acute perforation and uncontrollable massive bleeding need to be treated surgically.