Crohn’s disease is an inflammatory disease of the intestine of unknown origin that can occur anywhere in the gastrointestinal tract, but is more prevalent in the terminal ileum and right hemicolectum. The disease and chronic nonspecific ulcerative colitis are collectively known as inflammatory bowel disease (IBD). The clinical manifestations of this disease are abdominal pain, diarrhea, intestinal obstruction, accompanied by fever, nutritional disorders and other extraintestinal manifestations. The course of the disease is prolonged, recurrent and not easily curable. The disease is also known as limited enteritis, limited ileitis, segmental enteritis and granulomatous enteritis. There is no cure, and many patients develop complications that require surgery, and the recurrence rate after surgery is high. The recurrence rate of the disease is related to the extent of the lesion, the strength of the disease invasion, the prolongation of the disease, and the increase in age, with a consequent increase in mortality. Crohn’s disease, also called segmental enteritis, is an uncontrolled segmental inflammation of the intestine caused by the entry of an unknown antigen into a sensitive individual, with recurrent recurrence. Severe cases can lead to perforation and obstruction, prevention is mainly aimed at the pathogenesis of the three links: 1, reduce the entry of antigens: try to restore the simple lifestyle of early life, such as non-smoking (including passive smoking), eat less excessive fried food; 2, restore a simple lifestyle: develop good habits of life and rest, reduce anxiety. Think about the major stressful events that occur in life; 3, reduce excessive reactions: can be long-term oral 5-ASA or Reglan to reduce excessive set-free reactions; 4, should also be regular follow-up: to obtain the experience and guidance of a specialist, regular colonoscopy, timely detection of early relapse, adjust drug therapy.