There is no such thing as “Glimepiride and Metformin which is better”, Glimepiride and Metformin belong to different types of hypoglycemic drugs, please follow the doctor’s instructions to choose the right hypoglycemic drug for yourself. Glimepiride belongs to sulfonylurea hypoglycemic drugs, can stimulate the pancreatic islet B cell secretion of insulin, improve the sensitivity of the surrounding tissues to insulin, can be used for the treatment of dietary control, exercise therapy and weight loss can not be very good control of blood sugar type 2 diabetes. It is contraindicated in allergy to this drug, type 1 diabetes mellitus, severe hepatic or renal insufficiency, pregnancy and lactation. Metformin belongs to the class of biguanide glucose-lowering drugs, can reduce the synthesis of glucose in the liver and intestinal absorption of glucose, and then reduce the blood sugar of diabetic patients, can be used to treat type 2 diabetes mellitus that can not be satisfactorily controlled by physical exercise and dietary control; allergic to this drug, suffering from renal disease, need to be treated with medication such as congestive heart failure and other groups of people are contraindicated. Adverse effects of glimepiride include hypoglycemia, nausea, vomiting, and skin allergy; adverse effects of metformin include hypoglycemia, nausea, vomiting, and lactic acidosis. Patients who need to be treated with glimepiride or metformin should be under the supervision of a doctor.