The difference between herpes simplex type I and type II lies in the different ways of transmission, different pathogens, different groups of people, and different sites of occurrence. 1. Different transmission routes: herpes simplex type 1 (HSV-Ⅰ) is usually infected through kissing or other close contact, herpes simplex type 2 (HSV-Ⅱ) is often transmitted through close sexual contact, and may occasionally be transmitted from mother to child. 2. Different pathogens: Herpes simplex type I is caused by infection with herpes simplex virus type 1, while herpes simplex type II is caused by infection with herpes simplex virus type 2. 3. Different prevalence groups: Herpes simplex type 1 occurs more often in young children under 5 years of age, while herpes simplex type 2 occurs more often in sexually active people, as well as immunocompromised, malnourished, suffering from lymphoma, atopic dermatitis, the use of immunosuppressant people are also prone to the development of the disease. 4. Different parts of the body: Herpes simplex type 1 is more common in parts above the waist, especially the face, such as herpes on the lips and mouth, herpes on the cornea of the eyes, etc., while herpes simplex type 2 is more common in the genitals. If any of the above conditions exist, it is recommended to consult a doctor to confirm the diagnosis, and under the guidance of the doctor for treatment.