Hepatitis B virus DNA 5.08E+05IU/ML indicates that the titer of hepatitis B virus in the body is very high and antiviral drugs may be needed. The titer of hepatitis B DNA in normal people is 0~100IU/ML, but there are some differences depending on the medical institutions. If its greater than 2.0E+05IU/ML, patients with acute hepatitis B or chronic hepatitis B with abnormal liver function and fibrotic changes in the liver need antiviral treatment. Hepatitis B antiviral drugs include entecavir, tenofovir, interferon, etc. For patients with hepatitis B diagnosed for the first time, entecavir is generally used without special circumstances, and tenofovir can be considered if the patient is a woman of pregnant age; interferon is prohibited for those with cirrhosis. The disease is different, the specific treatment plan is different, it is recommended to go to the hospital, the professional hepatologist to develop a treatment plan.