Skin allergies can be caused by a variety of factors, both endogenous and exogenous. Skin allergies require daily supplementation of vitamin C, vitamin D, vitamin E and B vitamins. Endogenous factors such as chronic infections such as chronic cholecystitis, endocrine metabolic changes such as menstrual disorders. Exogenous factors such as consumption of fish, shrimp, beef and mutton, inhalation of pollen, contact with chemical substances, etc., need to seek medical advice to find the cause. Vitamin C has strong antioxidant properties, which can maintain the permeability of human blood vessels and promote metabolism. Vitamin D plays an important role in skin immune regulation. Vitamin E can help alleviate the dryness of the skin during the allergy period, while B vitamins can improve skin roughness, regulate the secretion of skin oil, and promote the repair of skin after allergy. However, it should be noted that vitamin supplements can not treat skin allergies, but can only improve and repair the skin after allergies. To treat the symptoms of skin allergies or need to follow the doctor’s instructions to use antihistamines, such as loratadine, etc., if necessary, external tacrolimus ointment, it is recommended to go to the hospital dermatology department for consultation.