Multiple bone metastases can be treated with local therapy, systemic chemotherapy, targeted therapy and palliative therapy, etc. It is recommended to have a comprehensive treatment according to the metastatic situation after further examination. 1. For multiple bone metastases, the main treatment is to target the primary lesion causing bone metastases, and surgical resection, surgical internal fixation, local radiation therapy, etc. can be carried out according to the condition of the primary lesion. 2. Systemic chemotherapy: for multiple metastatic foci, chemotherapeutic drugs such as doxorubicin and cyclophosphamide can be injected orally or intravenously to carry out systemic chemotherapy, so as to achieve the therapeutic purpose of killing cancer cells with chemotherapeutic drugs. 3. Targeted therapy: Besides, anti-tumor drugs such as cabozantinib can be carried by nano-materials through targeted drug delivery system for targeted therapy. 4. Palliative treatment: For advanced cancer patients, palliative treatment can be carried out with the purpose of reducing symptoms, and non-steroidal anti-inflammatory drugs such as morphine can be applied to reduce pain. Therefore, it is recommended to formulate comprehensive treatment measures based on imaging combined with the patient’s own situation under the guidance of the doctor.