The patient’s platelet count of 90 x 10^9 platelets/L indicates that the patient’s cirrhosis has entered the stage of hepatic decompensation, which is a very serious signal. Hepatitis B patients will experience pathological changes such as cirrhosis and portal hypertension as the disease progresses, and a decrease in platelet count is an early sign of portal hypertension. Normal platelet count is (100~300)×10^9 cells/L. The fact that the patient’s platelet count has fallen below normal indicates that the patient has developed the pathophysiologic changes of portal hypertension and hypersplenism. Cirrhosis has entered the stage of hepatic decompensation, after which the patient’s condition may change drastically, and serious complications such as hepatic encephalopathy, hepatopulmonary syndrome, and rupture and bleeding of esophagogastric fundic varices may occur, which may endanger the patient’s life. Patients should go to the gastroenterology department of the local hospital as soon as possible, and can be treated with antiviral drugs such as tenofovir, adenosylmethionine to protect hepatocytes, and splenectomy for the decrease of platelet count caused by portal hypertension. The specific treatment varies depending on the severity of the patient’s condition, and it is necessary to follow the instructions of the physician and actively cooperate with the treatment to minimize the complication and improve the prognosis.