Watery stool perianal pain may be caused by diarrhea stimulation of the perianal mucosa, patients can improve the symptoms through general treatment, medication and other ways. 1. General treatment: patients should pay attention to personal hygiene, each time after defecation, timely use of water to wash the anal area to reduce the stimulation of water stool on the anal skin, but also through the warm water sitz bath and other ways to relieve the pain, in addition, patients should also pay attention to the diet, try to eat a light diet, to avoid spicy and stimulating food. 2. Medication: For patients with diarrhea caused by gastroenteritis, anti-infective treatment, such as azithromycin and sulfamethoxazole, etc., anti-diarrheal drugs, such as montelukast, etc., and probiotics, such as Bifidobacterium tetrapartum tablets, etc., can be used to regulate the diarrhea under the direction of a doctor. For patients with severe diarrhea and pain can take anticholinergic drugs, such as pivotal ammonium bromide tablets, etc., in order to antispasmodic and analgesic, slow down gastrointestinal peristalsis and so on. If the patient has hemorrhoids, anal fissure and other conditions, you can use local topical lidocaine, Ma Yinglong hemorrhoidal cream, anus tylenol ointment and so on for treatment. In addition, it is recommended that patients strictly follow the doctor’s instructions for medication, actively cooperate with the doctor’s treatment, pay attention to monitoring the condition in life, if there is any abnormality timely medical treatment, etc., to avoid delaying the condition.