The dose of diphenhydramine antihypertensive drug can be gradually reduced while increasing the drug of sartan, and gradually change the drug of diphenhydramine to the drug of sartan. Dipyridamole belongs to calcium antagonist, patients who are not sensitive to dipyridamole or cannot tolerate it can gradually reduce the dose of dipyridamole and increase sartans at the same time, and then monitor the blood pressure level, and gradually stop dipyridamole and completely replace it with sartans when the blood pressure level is stable to avoid sudden change of medication to avoid fluctuation of blood pressure level. Adverse effects of diphenhydramine antihypertensive drugs include facial flushing, lower limb edema, dry stools, tachycardia, etc. They are contraindicated in patients who are allergic to the components of the drug, have severe hypotension, or have severe stenosis of the aortic valve. Adverse reactions to antihypertensive drugs of the sartan class include nausea, vomiting, flu-like symptoms, rhinitis, cough, increased creatinine, joint pain, etc. They are contraindicated in patients who are allergic to the components of the drug, severe renal insufficiency, breastfeeding and women during pregnancy. When replacing diphenhydramine drugs with sartans, use the drug under the guidance of a physician and avoid self-adjustment.