In our daily life, almost everyone has experienced bone pain, such as back pain, chest pain, back pain, leg pain, etc., to a lesser or greater extent, for a longer or shorter period of time, with some pain relieving on its own or improving after treatment by a doctor. The majority of these pains are benign in nature, but there is one type of bone pain that we cannot ignore, and that is the bone pain caused by multiple myeloma. Bone pain, often the first symptom of multiple myeloma, is one of the most important symptoms of the disease. About 2/3 of patients visit the doctor for bone pain. Domestic statistics show that 55.2%-73.9% of patients have bone pain as their first symptom. This bone pain is non-specific and varies in severity. Early bone pain is often mild, temporary, and can be wandering or intermittent. Therefore, in the early stage of the disease many patients are misdiagnosed as rheumatism, rheumatoid arthritis, costochondritis, osteophytes, herniated disc, osteoporosis, lumbar sprain, bone tuberculosis, etc. Many patients initially do not go to the hematology department, but to other departments such as orthopedics, etc. As the disease progresses, bone pain may become persistent and severe, and even pathological fractures may occur. So, can bone pain caused by multiple myeloma be alerted by the general population at a relatively early stage? What characteristics of bone pain must be considered multiple myeloma? Let’s take a look at what are the characteristics of bone pain in multiple myeloma. 1.Since myeloma cells initially invade the bone marrow hematopoietic tissue, there are more myeloma cells in the hematopoietic rich bone marrow tissues, the bone tissue is more seriously damaged, and bone pain is easy to occur, these bone tissues mainly include vertebrae, pelvis, ribs, skull, scapula and other flat bone tissues, so bone pain of multiple myeloma mostly occurs here. 2. Since myeloma cells invade diffusely with the bone marrow, the resulting bone damage is extensive, so bone pain may occur not in a single place but in many places, or the bone pain may start in one place and gradually become multiple bone pains. Some data show that the bone disease in patients with multiple myeloma occurs in a single site (18.06%) and in multiple sites (more than 2 sites) (81.94%). 3. Due to the thin bone cortex of flat bones and the weight or force on the bones, bone pain is most common in the lumbosacral region, followed by the thoracic rib region, and less in the long bones of the extremities. In addition, conventional symptomatic treatment has no obvious effect, and some physical treatments such as massage often aggravate bone pain. 4. Since multiple myeloma can produce a large amount of abnormal monoclonal immunoglobulins and other clinical manifestations such as anemia, proteinuria and infection, we should be very alert to the occurrence of multiple myeloma if bone pain is accompanied by other clinical manifestations such as anemia, infection and renal insufficiency, or if laboratory tests suggest increased blood sedimentation and hyperimmunoglobulinemia. In conclusion, if unexplained bone pain occurs, or if bone pain is accompanied by other adverse reactions, you should see a hematologist as soon as possible.