The treatment of multiple myeloma is mainly based on chemotherapy, which is the common treatment for multiple myeloma. Chemotherapy includes single-agent chemotherapy and combination chemotherapy. Single-agent chemotherapy can be treated with cyclophosphamide, adriamycin, nitrogen mustard drugs, vincristine and doxycycline, while combination chemotherapy often uses 2-3 drugs effective for myeloma alone to form a combination chemotherapy regimen, so as to achieve a therapeutic effect on myeloma. Bortezomib-based combination chemotherapy is currently recommended internationally. Another treatment modality is the use of high-dose chemotherapy followed by hematopoietic stem cell transplantation, which has also yielded good results in recent years. For patients with limited multiple myeloma, local radiation therapy can be used to relieve the tumor lesions and reduce the symptoms of bone pain caused by myeloma. The management of complications in the treatment of multiple myeloma is more important, such as the prevention and treatment of bone pain, renal failure, hypercalcemia, spinal cord compression, and infection.