Generally speaking, the danger of high bilirubin is manifested in jaundice, itchy skin, damage to the liver, damage to the nervous system and so on. 1. Jaundice:High bilirubin is usually deposited in the sclera and skin area, which leads to yellowing of eyes and skin and jaundice. 2. Itchy skin: In some patients, itchy skin may be caused by high bilirubin stimulating the peripheral nerves. 3. Damage to the liver: drug-induced high bilirubin may damage liver function, affecting bile secretion will affect the digestive function. 4. Damage to the nervous system: Bilirubin is toxic, if high bilirubin may cause damage to the nervous system. If high bilirubin occurs, it is recommended to consult a doctor to identify the cause of the disease and to carry out targeted treatment or therapy.