Weak positivity of anti-SCL-70 antibody suggests that the patient may have systemic sclerosis, CREST syndrome and other diseases, it is recommended that the rheumatology and immunology department consult the doctor, under the guidance of the doctor to further improve the relevant auxiliary examinations to clarify the diagnosis and carry out targeted treatment. Anti-SCL-70 antibody is a kind of autoantibody closely related to systemic sclerosis, named after its molecular weight of 70kd. In addition to systemic sclerosis, positive anti-SCL-70 antibody can also be seen in CREST syndrome. Therefore, patients with weakly positive anti-SCL-70 antibody test results need to further improve the blood sedimentation, X-ray, CT and other auxiliary examinations, as well as based on clinical manifestations and physical signs to clarify the diagnosis. Systemic sclerosis and CREST syndrome are mainly treated by drugs, and commonly used drugs include immunosuppressants such as cyclophosphamide, azathioprine, mertiomacrophenol ester, etc., vasodilators such as nifedipine, aspirin and prostacyclin. The above drugs must be used under the supervision of a physician. Laboratory test results need to be interpreted by a professional physician, it is recommended that patients with weakly positive anti-SCL-70 antibody test go to the Department of Rheumatology and Immunology of a regular hospital for detailed consultation.