The use of hydrocortisone butyrate is occasionally associated with allergic reactions, and in the case of prolonged use, it can cause localized skin atrophy, hyperpigmentation, capillary dilatation, as well as secondary infections and other adverse reactions. Hydrocortisone butyrate is a glucocorticoid drug, topical application, the drug can be used for the treatment of seborrheic dermatitis, allergic, dermatitis, atopic eczema, mossy pruritis and other skin diseases, it can play the effect of anti-allergy, anti-inflammatory, anti-itching and reduce exudation. Adverse reactions caused by hydrocortisone butyrate under long-term use include capillary dilatation, localized skin atrophy, hyperpigmentation, secondary infection; in addition, occasional allergic reactions have been seen in some groups of people after the use of the drug. Contraindications: Hydrocortisone butyrate should not be used in people with infectious skin diseases. It must also be contraindicated in people who are allergic to the drug. Precautions: Hydrocortisone butyrate should not be used in areas of broken skin, and avoid contact with the eyes, or other mucous membrane areas. After using the medication, if you find unusual redness, swelling, burning sensation and other discomforts at the site of application, you should be careful to stop the medication in time and wash the local medication clean, and seek professional medical help if necessary. Although hydrocortisone butyrate is an over-the-counter drug, individuals should avoid abusive behavior and consult a professional physician or pharmacist before using the drug.