Tumor patients are different from ordinary acute and chronic patients, most of them have fantasy, fear, pessimism, anxiety, anger, irritability, selfishness and other psychology and emotion, they think they are suffering from incurable disease, and in the end, they will be empty. Nurses should grasp the psychological changes of patients, observe their abnormal behaviors, and take timely measures to intervene to prevent adverse consequences. The types of psychological reactions of cancer patients are related to their own personality, psychological characteristics, severity of disease and cancer awareness. The main psychological reactions of cancer patients can be divided into six stages: experience period, doubt period, fear period, fantasy period, despair period and calm period. 1.Experience stage When a patient sees the test result or learns that he/she has cancer, he/she will be in a state of confusion, the sky is falling, he/she cannot believe his/her eyes and feels that he/she is sentenced to death, thus he/she will be numb and even faint. This period is brief and can last for a few hours or days. The goal of care during this period is to establish a trusting relationship with the patient, provide support, and express emotional comfort and concern to the patient. The nurse should mobilize the family to be with the patient, hold the patient’s hand gently or maintain appropriate physical contact to make the patient feel secure and that he is not alone in his misfortune. 2.Suspicious period The patient strongly denies the diagnosis, and even goes to several hospitals or pretends to be the patient’s family to consult the doctor. At this time, the patient and the doctor have not established a trusting relationship, and they both hope to confirm the diagnosis and hope to hear a diagnosis that is not cancer. The patient’s denial attitude cannot be simply evaluated as a negative psychological state. This refusal to accept the facts is a psychological response to trauma or stress state, which is a protective response that can reduce the patient’s fear level, ease the painful experience and gradually adapt to the unexpected blow. The nurse does not need to rush the patient to accept the reality and keep the patient from being hit as hard as possible. A strategy appropriate to this patient should be adopted so that he can gradually understand the truth and allow the patient to express his feelings and thoughts to his heart’s content and eventually accept the treatment plan. During the persuasion process, the patient should always be made to feel that he or she is the master, maintain his or her self-esteem, meet the patient’s needs in terms of heart and treatment, and provide the spiritual strength that can support the patient. 3. Fear period Fear arises when desperate denial still fails to change the diagnosis. This includes fear of disease, fear of pain, fear of leaving family and friends, fear of physical defects, fear of death, etc. Patients exhibit panic, crying, vigilance, provocative behavior, impulsive behavior, and a range of physiological changes, such as tremors, palpitations, increased blood pressure, pale skin, and sweating. Fear is an adaptive response that allows a person to be more attentive and alert to risk factors and to adopt avoidance or aggression to reduce the risk. By talking with the patient, the nurse allows the patient to tell the story before and after he or she felt fear, corrects the patient’s perception errors through education about the knowledge, or allows other patients to tell of having successfully dealt with the same fearful scenario to make the patient feel more secure. Although fear is a normal human psychological defense mechanism, but the long-term existence of fear will cause a series of psychological problems and physical diseases. 4. Fantasy period When the patient has experienced various painful experiences after getting sick, he can already face the reality, but there are many fantasies, such as hoping for a miracle, hoping to invent a new drug to eradicate his disease. Of course, fantasies do not necessarily have a negative impact on the patient, but on the contrary can support the patient to fight against the disease, increase confidence, improve coping skills, and improve the level of fear and anxiety. We often see such examples in the clinic, when people have certain fantasies, easily accept the comfort of others, have good compliance behavior, once the fantasy is broken, the patient loses confidence in treatment to produce hunger strike, refusal to treatment behavior, and even the emergence of suicidal thoughts. 5, desperate period When all kinds of treatment methods can not achieve good results, further deterioration of the disease, and even serious complications, the patient despair, lose confidence in treatment, do not listen to the persuasion of medical staff and family, friends, and even suicidal thoughts, the patient manifested as irritable, antagonistic mood, disobedience, non-compliance with medical advice, etc.. At this time, the patient should be given more comfort, allow the patient to vent his anger, and let the patient’s closest family members accompany him. When the disease develops to an advanced stage, the patient is in a state of passive coping, no longer considering his obligations to family and society, focusing on his own symptoms, and in a hopeless and helpless state. The nurse should communicate more with the patient and meet his or her needs. Provide them with information full of hope for life and work with them to develop a survival plan.