Knee pain from falling off a ladder stool may be caused by sprain, tibial plateau fracture, synovitis and other conditions, according to the cause of the drug treatment, surgical treatment, general measures and so on. 1. Sprain: Usually, patients can apply local ice packs and elevate the affected limb appropriately for regular observation. If the patient’s pain and other symptoms are more serious, you can also use aspirin, indomethacin and other anti-inflammatory analgesics for treatment. Some patients also need to use elastic bandage or inflatable immobilizer for local compression, so as not to aggravate the swelling. 2. Tibial plateau fracture: usually patients need to use plaster for local immobilization under the guidance of the doctor, and take diclofenac sodium, celecoxib and other analgesic treatment. Patients can also take antibiotics such as cefuroxime and head ampicillin to prevent infection. If the condition is serious, internal fixation surgery can be carried out, and functional exercises can be carried out after the operation. 3. Synovitis: Usually patients can be treated with non-steroidal anti-inflammatory drugs such as ibuprofen and etoricoxib, and topical diclofenac ethylenediamine emulsion is also needed. In case of acute purulent synovitis, antibiotics such as cefoxitin and cefotaxime are also needed to prevent infection. If necessary, arthroscopic surgery under the supervision of a doctor is also required. When the symptoms of knee pain occur after falling off a ladder stool, it is recommended to seek medical attention in a timely manner, and reasonable treatment according to the cause of the disease.