Pain in the chest in the middle of the night may be caused by acute gastritis or gastric ulcer perforation. The patient will experience pain in the upper abdomen, which is very intense, along with nausea, vomiting, acid reflux, etc. If the perforated gastric ulcer causes a significant increase in the internal leakage of fluid from the abdominal cavity, there will also be abdominal distention, and the anus will stop passing gas and stool, etc. If necessary, you can go to the emergency room for examination, first of all, you need to perform abdominal plain film or abdominal CT examination. If free gas is found in the abdominal cavity or under the diaphragm, it is considered to be caused by perforation of the digestive tract and requires emergency surgery. If no free gas is found in the abdominal cavity, it is usually considered to be caused by gastritis and requires oral gastric medicine for treatment. For a definitive diagnosis, gastroscopy can be performed because it can detect lesions in the gastric mucosa and a small amount of tissue can be taken for pathological examination. If the diagnosis of gastroscopy is acute gastritis, oral gastric medication such as omeprazole or rabeprazole is required.