The causes of pain in the middle of the chest after staying up late mainly include the following aspects: First, it is considered to be caused by the body’s cardiovascular system diseases, mostly due to the usual history of myocardial ischemia and exertional angina and other underlying diseases, coupled with recent work strain or emotional tension, resulting in an increase in myocardial blood supply, which in turn causes pain in the middle of the chest. When staying up late, the human body endocrine disorder, which will aggravate myocardial ischemia, will cause pain in the middle of the chest, you need to take drugs to improve myocardial blood supply, as well as regular rest and relaxation can be alleviated. Secondly, it is considered to be due to sympathetic excitation of the body after staying up late, which causes intercostal nerve pain, resulting in pain in the middle of the chest. The intercostal nerve pain is mostly obvious at night, and the pain increases when resting or resting, while during the day or at work, the pain can be relieved.