The duration of action of glipizide varies with different dosage forms. Generally speaking, glipizide tablets and glipizide capsules can work for more than 10 hours, and controlled-release tablets and extended-release tablets can last for about 24 hours. Glipizide is a kind of hypoglycemic drug, which is suitable for patients with type 2 diabetes mellitus whose dietary control and physical exercise are not effective, and the common dosage forms are tablets, controlled-release tablets, extended-release tablets and capsules, etc. Glipizide tablets are usually taken orally. Glipizide tablets are generally absorbed through the small intestine after oral intake, the effect is seen in 30~40 minutes, and the peak blood concentration is reached in 1~3 hours, the peak time of Glipizide capsules is about 1~2 hours, and the maintenance of hypoglycemic effect of the tablets as well as capsules is generally more than 10 hours. Glipizide controlled-release tablets are rapidly and completely absorbed after oral administration, blood concentrations begin to rise 2~3 hours after oral administration and peak within 6~12 hours, and glipizide extended-release tablets generally reach the highest blood concentration at 11.6±5.54 hours. Both are able to maintain effective blood levels over a 24-hour dosage interval when given once daily consecutively. It is recommended that they be used under the supervision of a physician at the time and in the doses prescribed. Adverse reactions such as insomnia, abnormal sensations, nausea, and constipation may occur after use, and medical attention should be sought in case of severe symptoms.