Patients with particularly itchy nipples on one side are advised to administer topical hormonal creams, such as Pirexone, for a continuous period of topical application to ensure symptom relief. When nipple itching occurs, in addition to addressing the symptoms, you need to understand the causes of nipple itching. For example, contact dermatitis and trauma can lead to breakage of the skin on the nipple surface and healing itching; the relatively rare but more serious cases of Paget’s disease and basal cell tumors can cause nipple breakage and make the patient itch. Patients should not only address the symptoms but also focus on the cause of the itching. It is recommended that patients visit a breast specialist for a detailed physical examination with relevant imaging to troubleshoot the problem and avoid missing the diagnosis.