Neonatal syphilis is treated like syphilis in adults, with penicillin-based antibiotics, the drug of choice for neonatal syphilis. As long as you are not allergic to the drug, you can use subcutaneous injections in sufficient amounts and courses to relieve symptoms as soon as possible. If you are allergic to penicillin antibiotics, you can apply macrolide antibiotic treatment, continuous use for a month, you can also achieve significant results. It is important to note that neonatal syphilis, can not be applied tetracycline antibiotics, in order to avoid adverse reactions. The development of the brain barrier of the newborn is imperfect, and if there is congenital syphilis, it will affect the nerves and appear neurosyphilis. This requires prompt use of glucocorticoid sedation to prevent neurosyphilis. If the symptoms of neurosyphilis have already appeared, the intracranial pressure is elevated, accompanied by fainting, and headache, etc., it is necessary to use dehydrating agents to reduce the intracranial pressure and relieve the condition at an early stage. So to summarize penicillin is the most effective drug for the treatment of syphilis, of which the most commonly used is benzylpenicillin, but also procaine penicillin can be used. Serologic tests need to be performed and followed up at months 2, 4, 6, 9, and 12 after treatment. A second regular treatment should be given if the test results do not fall or are elevated. It is recommended that patients go to a regular hospital, under the guidance of a professional physician, reasonable use of medication, not blindly self-medication, so as not to delay the condition, affecting the healthy growth of newborns.